The ENSPRYNG treatment schedule
A monthly treatment for neuromyelitis optica spectrum disorder (NMOSD) that you can take at home
A monthly treatment for neuromyelitis optica spectrum disorder (NMOSD) that you can take at home
ENSPRYNG is an injection that is given under the skin once a month via a prefilled syringe, giving you treatment flexibility and control over where you take it. ENSPRYNG is given every 4 weeks after taking 3 starter doses in your first month of treatment. With proper training, and provided your healthcare provider says it’s okay, you or your caregiver can administer ENSPRYNG.
Once you're ready, ENSPRYNG can be given in the comfort of your own home, or even while traveling. ENSPRYNG, if unopened, can be removed from and returned to the refrigerator, if needed. The total combined time out of the refrigerator should not be more than 8 days at a temperature that does not go above 86°F (30°C).
If a starting dose is missed, you should take it immediately, then maintain the 2-week dosing interval from your new starting date until the first 3 doses are complete, and then continue with ongoing doses every 4 weeks.
If an ongoing dose is missed, you should take it immediately, wait the 4-week interval from your new starting date, and then continue with ongoing doses every 4 weeks.
Speak with your healthcare provider if you have any questions about how to restart treatment or if it has been more than 8 weeks since your last dose of ENSPRYNG.
Get the details about what it's like to take ENSPRYNG from a Clinical Education Manager.
Voice-Over:
The subject of this video is Taking ENSPRYNG. ENSPRYNG is a prescription medicine used to treat neuromyelitis optica spectrum disorder, also known as NMOSD, in adults who are aquaporin-4, also known AQP4, antibody positive. It is not known if ENSPRYNG is safe and effective in children.
ENSPRYNG may cause serious side effects including infections, increased liver enzymes, and low neutrophil counts. All required vaccinations should be completed before starting ENSPRYNG. Do not take ENSPRYNG if you are allergic to satralizumab-mwge or any of the ingredients in ENSPRYNG, have an active hepatitis B infection or have active or untreated inactive (latent) TB.
Please see Important Safety Information at the end of this video. If you have any questions, please talk to your healthcare provider or refer to the ENSPRYNG Prescribing Information and Medication Guide.
This video features a Clinical Education Manager and a real person who is treating her NMOSD with ENSPRYNG.
DONNA:
Hello. My name is Donna. I was diagnosed with AQP4 positive NMOSD in 2014. So if you were diagnosed with NMOSD, I know what you’re going through as you look to learn more about this rare disease and consider your treatment options. This is one video in a series. I wish I would have had these videos to turn to when I was first diagnosed.
I’m now going to introduce you to Annette who is a Clinical Education Manager, also known as a CEM. Their job is to provide supplemental injection training to patients who have been prescribed ENSPRYNG and to caregivers when needed.
ANNETTE:
Thanks, Donna. Hello there, my name is Annette. I am a CEM with Genentech. I provide supplemental injection training and refresher supplemental injection training to patients and their caregivers, provided of course your doctor says you can self-inject with ENSPRYNG. I have guided many patients through this process. If you have questions or need a refresher, a CEM like me is there to support you during every step of this process.
ENSPRYNG is a monthly self-injectable treatment you can take on the go. You have a voice in how you manage your NMOSD treatment. If your healthcare provider determines it’s appropriate and after proper training, you or your caregiver have the ability to give it in the comfort of your own home or even while traveling, since ENSPRYNG can be stored at room temperature for a total of up to eight days, which don’t need to be eight days in a row.
ENSPRYNG is an injection that is given under the skin once a month via prefilled syringe, which gives the treatment flexibility and control over where you take it. Before and while taking ENSPRYNG, your healthcare provider may order tests and monitor you to ensure ENSPRYNG is still appropriate for you. Now that we’ve spoken about how ENSPRYNG is administered, let’s examine a chart that explains the dosing schedule for ENSPRYNG.
ENSPRYNG is a treatment that is given every four weeks after taking three starting doses in the first month of treatment. Here’s how the starting doses work. For the first four weeks, you are given one dose every two weeks. After that, you take one dose every four weeks. Doses are administered in a prefilled syringe that contain 120 mg of medicine. If a starting dose is missed, you should take it immediately, then maintain the two-week dosing interval from your new starting date until the first three doses are complete and then continue with ongoing doses every four weeks.
If an ongoing dose is missed, you should take it immediately. Wait the four-week interval from your new starting date and then continue with ongoing doses every four weeks.
Of course, you should always consult with your healthcare provider when it comes to administering the treatment they prescribed for you. As a CEM, I am also available to help answer questions you may have about self-injecting with ENSPRYNG.
One common question I get is how to store and handle ENSPRYNG which is the subject of our next slide. Follow these simple rules when storing and handling ENSPRYNG. Store ENSPRYNG in your refrigerator in its original box.
That protects it from light. If needed, unopened ENSPRYNG, can be removed from and returned to your refrigerator prior to administering it. Never freeze or shake the syringe. If for some reason the ENSPRYNG has to be stored at room temperature like when traveling, the total combined time out of the refrigerator should not be more than eight days at a temperature that is higher than 86 degrees Fahrenheit or 30 degrees Celsius.
I hope the information I shared with you today about taking ENSPRYNG was useful. Self-injection with ENSPRYNG can give you the flexibility to take it at a location that’s convenient for you, provided your healthcare provider determines it is appropriate and you have been trained on the proper technique.
Remember, if you are ever unsure and/or need to go over any of these steps again, you can always reach out to your CEM or even your Patient Navigator by calling 1-844-NSPRYNG. If they can’t answer a question, they can always point you in the right direction. Thank you for your time.
Now, let’s go back and get a closing thought from Donna, our Patient Ambassador.
DONNA:
Thanks, Annette. Living with NMOSD has brought certain challenges. Putting eye makeup on is not easy nor is playing pickleball. I lacked depth perception so I have a hard time figuring out where the ball is in relation to my paddle.
My sister and I laughed about it until we cried but we had fun trying. Being able to laugh at myself and find joy in everyday life has really made living with NMOSD bearable. After working with my doctor, I’m comfortable self-injecting with ENSPRYNG. For me, it’s empowering. I hope you found this video informative and helpful. Check out all the other videos in the series relating to ENSPRYNG at www.ENSPRYNG.com.
They are a valuable resource you can view any time. You can even watch them more than once as a refresher. Thanks for listening. Stay tuned for additional Important Safety Information.
Receive information about ENSPRYNG and the support options available to you
Hear stories from others living with NMOSD about their path from diagnosis to treatment
The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Genentech, Inc. makes no representation as to the accuracy of the information contained on sites we do not own or control. Genentech does not recommend and does not endorse the content on any third-party websites. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.