How to inject ENSPRYNG
Understand the steps involved with taking ENSPRYNG
ENSPRYNG injection training video
This video gives you step-by-step instructions on how to properly administer ENSPRYNG and is available in English and in Spanish below. You should be trained by your healthcare provider for your first dose. Then use this video, along with the ENSPRYNG Instructions for Use, to refresh what you learned.
ENSPRYNG injection training
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ENSPRYNG Injection Training Video
Narrator: How to self-administer ENSPRYNG. ENSPRYNG is indicated for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive.
Narrator: Today, we’re going to review how to self-administer ENSPRYNG.
Narrator: An adult patient or caregiver may inject ENSPRYNG after receiving proper training from a healthcare professional.
Narrator: For important safety information, please see the end of the video. We encourage you to watch this video more than once.
Narrator: If you have any questions, please talk to your healthcare provider or refer to the ENSPRYNG Instructions for Use, which provides more detailed information.
Narrator: The Preparation
Narrator:
Let’s get started. Take the box containing your ENSPRYNG syringe out of the refrigerator.
Check the expiration date on the back of the box and the seal on the front of the box. If the date is past or the seal is broken, do not use.
Dispose of the syringe per the instructions for use and contact your healthcare provider.
Open the box. Gently lift the syringe by the barrel and pull it out.
Check the expiration date on the syringe. The liquid should be clear and colorless to pale yellow. Some small bubbles are normal. If the syringe is damaged or expired, or the liquid is cloudy, discolored, or has particles in it, do not use.
Place the syringe on a clean, flat surface, set a timer for 30 minutes and let it come to room temperature. Keep it away from heating sources; do not warm up the syringe in direct sunlight, in a microwave, or with hot water.
While you wait, you can gather the supplies you need for the injection: 1 alcohol pad, 1 sterile cotton ball or gauze, and 1 small bandage.
SFX: DING OF KITCHEN TIMER.
Narrator: The Injection
Narrator:
First, wash your hands with soap and water.
Next, choose an injection site on your body.
The front or middle of your thighs, here, or the lower part of your stomach, here are good spots. Do not inject through clothing. Do not inject into moles, scars, bruises or areas where the skin is tender, red, hard or broken. The site should not be within 2 inches of your belly button.
Where you inject must be at least 1 inch away from where you last injected.
Next, wipe the injection site with an alcohol pad. Let it air dry, and do not touch it.
If you need help with the injection, ask a friend, family member, or caregiver to assist you.
Are you ready? Taking a deep breath can help you focus.
Take the cap off the needle and immediately dispose of it in an FDA-approved sharps disposal container. Use the syringe within 5 minutes, or the needle may clog. Do not touch the needle or let it touch any surfaces. Keep it away from children.
Hold the barrel of the syringe using your thumb and index finger. With your other hand, pinch the area of the skin you have cleaned. Use a quick, dart-like motion to insert the needle at an angle between 45 to 90 degrees. Do it just once. Let go of the pinched skin.
Then slowly inject the medicine by gently pushing the plunger all the way down.
Gently release the plunger.
SFX: CLICK
The needle shield should now cover the needle. If not, dispose of it carefully.
Check the injection site: do not worry if there’s a little bleeding or drop of medicine. You can press a cotton ball or gauze on it, but do not rub it. If needed you can cover it with a small bandage. If the medicine comes in contact with your skin, wash with water.
That’s it. You did it. Now all you have to do is clean up.
Narrator: The Clean-Up
Narrator:
Immediately place the used ENSPRYNG syringe in an FDA-approved sharps disposal container, not in your household trash, per the Instructions for Use.
Over time the container will fill up, so make sure you dispose of the used sharps disposal container as instructed by your healthcare provider or pharmacist.
Narrator: If you have any questions about self-injecting with ENSPRYNG, call: 844-677-7964. If you have any issues with your medication, please talk with your healthcare provider.
Video de capacitación para la inyección de ENSPRYNG
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Video de capacitación para la inyección de ENSPRYNG
MUJER (tarjeta de título): Cómo administrarse ENSPRYNG. ENSPRYNG está indicado para el tratamiento del trastorno del espectro de la neuromielitis óptica (NMOSD) en pacientes adultos con resultado positivo de anticuerpos anti-acuaporina-4 (AQP4).
MUJER (tarjeta de título): Vamos a repasar cómo administrarse ENSPRYNG.
MUJER (tarjeta de título): Un paciente adulto o un cuidador puede inyectar ENSPRYNG si un proveedor de atención médica le enseña cómo hacerlo.
MUJER (tarjeta de título): Para obtener información de seguridad importante, vea el final del video.
MUJER (tarjeta de título): Le recomendamos que mire este video más de una vez. Si tiene alguna pregunta, hable con su proveedor de atención médica o consulte las Instrucciones de uso de ENSPRYNG, que ofrecen información más detallada.
MUJER (tarjeta de título): La preparación
MUJER (animación):
Comencemos. Saque la caja con la jeringa de ENSPRYNG del refrigerador.
Verifique la fecha de expiración en la parte posterior de la caja y el sello en la parte delantera. Si la fecha ya pasó o el sello está roto, no la use.
Deseche la jeringa según las Instrucciones de uso y contacte a su proveedor de atención médica.
Abra la caja, levante la jeringa por el cilindro y sáquela de la caja.
Verifique la fecha de expiración en la jeringa. El líquido debe ser incoloro o amarillo claro. Es normal que haya burbujas pequeñas. Si la jeringa está dañada o vencida o el líquido está turbio, decolorado o con partículas, no la use.
Coloque la jeringa en una superficie plana limpia. Fije una alarma en 30 minutos para que la jeringa alcance la temperatura ambiente. No la exponga a fuentes de calor; no entibie la jeringa bajo la luz solar directa, en un microondas o con agua caliente.
Mientras espera, reúna los suministros necesarios: una almohadilla con alcohol, una bola de algodón o venda esterilizados y una venda adhesiva pequeña.
SFX: LA ALARMA.
MUJER (tarjeta de título): La inyección.
MUJER (animación):
Primero, lávese las manos con agua y jabón.
Luego, elija una zona para la inyección.
La parte frontal o media de los muslos aquí o la parte inferior del estómago aquí son buenas zonas. No se inyecte a través de la ropa. No se inyecte en lunares, cicatrices, moretones o zonas de la piel sensibles, rojas, duras o abiertas. La zona no debe estar a menos de dos pulgadas del ombligo.
La zona debe estar al menos a una pulgada de donde se inyectó la última vez.
Limpie la zona de la inyección con la almohadilla con alcohol. Deje que se seque al aire y no la toque.
Si necesita ayuda con la inyección, pídale ayuda a un amigo, familiar o cuidador.
¿Todo listo? Respire profundo para concentrarse.
Saque la tapa de la aguja y deséchela en un contenedor para materiales punzocortantes aprobado por la FDA. Use la jeringa antes de los cinco minutos para que no se obstruya. No deje que la aguja toque nada. Manténgala alejada de los niños.
Sostenga el cilindro de la jeringa con el pulgar y el dedo índice. Con la otra mano, pellizque la piel que limpió. Con un movimiento rápido, inserte la aguja en un ángulo de 45 a 90 grados. Hágalo solo una vez.
Suelte la piel e inyecte lentamente el medicamento empujando el émbolo hasta que haga tope.
Suelte suavemente el émbolo.
SFX: CLIC.
La aguja debe quedar cubierta por el cobertor. Si no es así, deséchela con cuidado.
Revise la zona de la inyección. No se preocupe si ve un pequeño sangrado o una gota de medicamento. Puede presionar con una gasa o algodón, pero sin frotar. Si es necesario, cúbrala con una venda adhesiva pequeña. Si el medicamento entra en contacto con su piel, lave el área con agua.
Eso es todo. Lo logró. Ahora solo tiene que limpiar.
MUJER (tarjeta de título): La limpieza.
MUJER (animación):
Coloque la jeringa ENSPRYNG usada en un contenedor para materiales punzocortantes aprobado por la FDA, no con la basura de la casa.
Con el tiempo, el contenedor se llenará. Deseche el contenedor usado según las instrucciones del proveedor de atención médica o farmacéutico.
MUJER (tarjeta de título): Si tiene preguntas sobre cómo inyectarse ENSPRYNG, llame al 844-677-7964. Si tiene problemas con el medicamento, hable con su proveedor de atención médica.
Tips for staying on track with treatment
It's important to stay on track with your ENSPRYNG injections. Keep track of the date of each dose and where it was given (left abdomen, right abdomen, left thigh, or right thigh), as you'll need to rotate injection sites. Make note of any reactions and how you felt, so you can discuss with your doctor. It can help to set reminders of your upcoming injection days in your phone or calendar.
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Important Safety Information & Indication
What is ENSPRYNG?
ENSPRYNG is a prescription medicine used to treat neuromyelitis optica spectrum disorder (NMOSD) in adults who are aquaporin-4 (AQP4) antibody positive. It is not known if ENSPRYNG is safe and effective in children.
Who should not receive ENSPRYNG?
Do not take ENSPRYNG if you:
- are allergic to ENSPRYNG or any of the ingredients in ENSPRYNG.
- have an active hepatitis B infection.
- have active or untreated inactive (latent) tuberculosis.
What is the most important information I should know about ENSPRYNG?
ENSPRYNG may cause serious side effects including:
- Infections. ENSPRYNG can increase your risk of serious infections, some of which can be life-threatening. Talk to your healthcare provider if you are being treated for an infection, or call them right away if you think you have signs of an infection, with or without a fever, such as:
- chills, feeling tired, muscle aches, cough that will not go away or a sore throat
- skin redness, swelling, tenderness, pain or sores on your body
- diarrhea, belly pain, or feeling sick
- burning when you urinate or urinating more often than usual
Your healthcare provider will check if you have an infection and treat it if needed before you start or continue to take ENSPRYNG.
- Your healthcare provider should test you for hepatitis and tuberculosis (TB) before you start taking ENSPRYNG.
- All required vaccinations should be completed before starting ENSPRYNG. People using ENSPRYNG should not be given ‘live’ or ‘live-attenuated’ vaccines. ‘Live’ or ‘live-attenuated’ vaccines should be given at least 4 weeks before you start ENSPRYNG. Your healthcare provider may recommend that you get a ‘non-live’ (inactivated) vaccine, such as some of the seasonal flu vaccines. If you plan to get a ‘non-live’ (inactivated) vaccine, it should be given, whenever possible, at least 2 weeks before you start ENSPRYNG.
- Increased liver enzymes.
Your healthcare provider should order blood tests to check your liver enzymes before and while you are taking ENSPRYNG. Your healthcare provider will tell you how often you will need to have these blood tests. Make sure you get all of your follow-up blood tests as ordered by your healthcare provider. Your healthcare provider will tell you if you need to wait to start ENSPRYNG if your liver enzymes are increased. - Low neutrophil count.
ENSPRYNG can cause a decrease in your neutrophil counts in your blood. Neutrophils are white blood cells that help the body fight off bacterial infections. Your healthcare provider should order blood tests to check your neutrophil count while you are taking ENSPRYNG. - Serious allergic reactions.
Serious allergic reactions that may be life-threatening have happened with other medicines like ENSPRYNG. Tell your healthcare provider before taking your next dose if you had hives, rash, or flushing after your injection. Seek medical attention right away if you have any symptoms of a serious allergic reaction, such as:
- shortness of breath or trouble breathing
- dizziness or feeling faint
- swelling of your lips, face, or tongue
- moderate or severe stomach (abdominal) pain or vomiting
- chest pain
Before you take ENSPRYNG, tell your healthcare provider about all of your medical conditions, including if you:
- have or think you have an infection. See "What is the most important information I should know about ENSPRYNG?"
- have liver problems.
- have ever had hepatitis B or are a carrier of the hepatitis B virus.
- have had or have been in contact with someone with tuberculosis.
- have had a recent vaccination or are scheduled to receive any vaccination.
- are pregnant, think that you might be pregnant, or plan to become pregnant. It is not known if ENSPRYNG will harm your unborn baby.
- Pregnancy Registry: There is a registry for pregnant women who take ENSPRYNG. The purpose of this registry is to check the health of the pregnant mother and her baby. If you are pregnant or become pregnant while taking ENSPRYNG, talk to your healthcare provider about how you can join this pregnancy registry, or you may contact the registry at 1-833-277-9338 to enroll.
- are breastfeeding or plan to breastfeed. It is not known if ENSPRYNG passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take ENSPRYNG.
Tell your healthcare provider about all the medicines you are taking, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the most common side effects of ENSPRYNG?
The most common side effects of ENSPRYNG include:
- sore throat, runny nose (nasopharyngitis)
- rash
- fatigue
- extremity pain
- headache
- upper respiratory tract infection
- nausea
- inflammation of the stomach lining (gastritis)
- joint pain (arthralgia)
These are not all the possible side effects of ENSPRYNG.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555.
For more information, call 1-844-NSPRYNG.
For additional safety information, please see the full Prescribing Information and Medication Guide.